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Standardisation and optimisation of magnetic resonance techniques for multicentre studies
1NMR Research Unit, Institute of Neurology, London, UK. p.tofts@ion.ucl.ac.uk
Journal of Neurology, Neurosurgery, and Psychiatry
|July 1, 1998
Summary
Accurate and precise measurement of lesion load using magnetic resonance imaging (MRI) is crucial for multicenter studies. Implementing quality assurance with phantoms and controls ensures reliable data, improving diagnostic accuracy in neurological conditions.
Area of Science:
- Medical Imaging
- Neurology
- Biophysics
Background:
- Multicenter studies require reliable measurement of physical quantities like lesion load.
- Current magnetic resonance imaging (MRI) techniques can exhibit inaccuracies and imprecision.
- Artefactual changes and spatial non-uniformity affect lesion volume measurements.
Purpose of the Study:
- To present an approach for accurate and precise MRI measurement of physical quantities in multicenter studies.
- To highlight the importance of accuracy and precision in MRI-based scientific measurements.
- To establish quality assurance procedures for multicenter MRI studies.
Main Methods:
- Analysis of imperfections in current MRI lesion load measurement techniques.
- Utilizing phantoms with known lesion volumes to assess accuracy (systematic error).
- Evaluating precision (random error) through repeated measurements on phantoms and human subjects.
Main Results:
- Identified artefactual decreases in lesion volume in serial trials.
- Demonstrated systematic error in lesion volume measurements using phantoms.
- Observed image shading due to spatial non-uniformity in radiofrequency coil sensitivity.
Conclusions:
- Measurement procedures must demonstrate phantom accuracy and precision.
- Repeated measurements on phantoms and human subjects are essential for precision.
- Quality assurance procedures are vital for reliable multicenter MRI studies.