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Immunolocalization of apolipoprotein D, androgen receptor and prostate specific antigen in early stage prostate
S X Zhang1, J M Bentel, C Ricciardelli
1Flinders Cancer Centre, Department of Surgery, Flinders University School of Medicine, Bedford Park, Australia.
Purpose:
To determine the cellular distribution and levels of immunohistochemical staining for apolipoprotein D (Apo-D), prostate specific antigen (PSA) and androgen receptor (AR) in early stage prostate cancers.
Materials And Methods:
Cellular distribution of Apo-D, PSA and AR in 30 stage A/B prostate cancers and in non-malignant glandular tissue contained in the same sections was detected immunohistochemically, and staining was evaluated by computerized video image analysis.
Results:
Staining for Apo-D (percentage positive cellular area) was significantly increased in tumor cells of early stage prostate cancers compared with non-malignant glandular tissue. PSA and AR were present at high levels in both early stage prostate tumors and non-malignant prostate.
Conclusions:
Malignant transformation in the prostate is associated with increased cellular levels of Apo-D.
