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Coenzyme Q10 fetal plasma levels
G Noia1, D Romano, M De Santis
1Department of Obstetrics and Gynecology, Catholic University of Sacred Heart, Rome, Italy.
Objective:
This study aims at determining a cutoff value differentiating the fetal from the adult coenzyme Q10 (CoQ10) values and comparing substantial increases in CoQ10 plasma levels in fetuses with hypoxic hypoxia and nonimmune fetal hydrops.
Methods:
We have selected 61 pregnancies and determined the CoQ10 levels in fetal and maternal samples obtained by cordocentesis. Our study included a control group and pregnancies with intrauterine growth retardation, Rh isoimmunization, nonimmune fetal hydrops, and fetal malformations.
Results:
To differentiate the fetal from the adult values we have set 0.3 mg/ml as the cutoff value. The CoQ10 were higher only in fetuses with hypoxic hypoxia and nonimmune hydrops.
Conclusion:
Normal fetal CoQ10 plasma levels are lower than 0.3 mg/ml.