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Related Experiment Videos

Body composition in systemic lupus erythematosus

Y Kipen1, B J Strauss, E F Morand

  • 1Department of Rheumatology, Monash Medical Centre, Clayton, Melbourne, Australia.

British Journal of Rheumatology
|July 3, 1998
PubMed
Summary

Systemic lupus erythematosus (SLE) and corticosteroid use negatively impact body composition, specifically reducing fat-free mass and bone mineral density (BMD) in women. Disease severity and steroid exposure are key factors affecting SLE patients' body composition.

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Area of Science:

  • Rheumatology
  • Endocrinology
  • Body Composition Analysis

Background:

  • Systemic lupus erythematosus (SLE) is a chronic autoimmune disease affecting multiple organ systems.
  • Body composition changes, including reduced lean mass and bone mineral density (BMD), are common in SLE patients.
  • Corticosteroid therapy, frequently used in SLE management, is known to adversely affect bone health and body composition.

Purpose of the Study:

  • To determine the body composition of female patients with SLE.
  • To investigate the effects of SLE disease severity and corticosteroid therapy on body composition in these patients.

Main Methods:

  • Cross-sectional study involving 82 female SLE patients.
  • Body composition assessed using dual-energy X-ray absorptiometry (DXA).

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  • Data collected via interviews, examinations, and medical record reviews, including SLE severity (SLICC) and corticosteroid exposure history.

    • Main Results:

    • Reduced fat-free mass was associated with higher SLE severity (SLICC), corticosteroid exposure, and age.
    • Lower total body BMD was linked to SLE severity, corticosteroid exposure, age, and menopausal status.
    • Fat-free mass independently predicted total body, lumbar spine, and femoral neck BMD.
    • Fat mass was associated with lumbar spine BMD.

    Conclusions:

    • SLE disease severity and cumulative corticosteroid exposure independently contribute to reduced fat-free mass and total body BMD in female SLE patients.
    • Fat-free mass is a significant predictor of BMD at multiple skeletal sites in this population.
    • These findings highlight the importance of monitoring body composition in SLE management.