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The development of bioengineered skin
R S Kirsner1, V Falanga, W H Eaglstein
1Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine (UMSM), FL, USA. dermatol@hutton.net
Trends in Biotechnology
|July 4, 1998
Summary
Tissue-engineered skin substitutes are being developed for burn patients. These advanced wound care products, including skin models, are now commercially available for challenging wounds.
Area of Science:
- Regenerative Medicine
- Biomaterials Science
- Wound Healing Research
Background:
- Extensive burns necessitate donor tissue, creating a demand for alternatives to autologous and cadaver-derived skin grafts.
- Over the past two decades, significant research has focused on developing engineered skin substitutes.
- Current alternatives aim to mimic the epidermal and dermal layers of natural skin.
Purpose of the Study:
- To review the development of skin substitutes for burn patients.
- To highlight the progression from basic models to commercially available products.
- To discuss the application of these products in managing complex wounds.
Main Methods:
- Development of unilayered and bilayered skin models.
- Utilizing cellular components and matrix materials in engineered skin.
- Clinical trials for acute and chronic wound applications.
Main Results:
- Successful development of various skin substitute models.
- Demonstrated efficacy in treating refractory and challenging wounds.
- Commercialization of several engineered skin products.
Conclusions:
- Engineered skin substitutes represent a significant advancement in regenerative medicine.
- These products offer viable alternatives for patients with extensive burns and complex wounds.
- Ongoing innovation continues to expand therapeutic options in wound care.