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Related Concept Videos

Biofilms01:29

Biofilms

Biofilms are complex communities of microorganisms encased in a self-produced extracellular polysaccharide matrix attached to surfaces. These microbial consortia can include single or multiple species, providing enhanced survival benefits by forming organized, multilayered structures.The formation of biofilms occurs through four key stages: attachment, colonization, development, and dispersal.During attachment, free-swimming planktonic cells adhere to a surface, often facilitated by...
The Skin Microbiota01:27

The Skin Microbiota

The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...
The Oral Microbiota01:27

The Oral Microbiota

The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Bacterial Signaling01:30

Bacterial Signaling

Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...

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Updated: May 20, 2026

Organotypic Tissue Model Systems for Investigating Host-Pathogen Interactions In Vitro
08:41

Organotypic Tissue Model Systems for Investigating Host-Pathogen Interactions In Vitro

Published on: March 28, 2025

Biofilms in dermatology.

A G Nusbaum1, R S Kirsner, C A Charles

  • 1Department of Dermatology & Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.

Skin Therapy Letter
|July 25, 2012
PubMed
Summary
This summary is machine-generated.

Biofilms, microbial communities on surfaces, are linked to 80% of human infections and skin disorders. Understanding biofilm biology is key to developing new treatments for these persistent, drug-resistant infections.

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Use of a High-throughput In Vitro Microfluidic System to Develop Oral Multi-species Biofilms
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Use of a High-throughput In Vitro Microfluidic System to Develop Oral Multi-species Biofilms

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Last Updated: May 20, 2026

Organotypic Tissue Model Systems for Investigating Host-Pathogen Interactions In Vitro
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Organotypic Tissue Model Systems for Investigating Host-Pathogen Interactions In Vitro

Published on: March 28, 2025

Use of a High-throughput In Vitro Microfluidic System to Develop Oral Multi-species Biofilms
07:09

Use of a High-throughput In Vitro Microfluidic System to Develop Oral Multi-species Biofilms

Published on: December 1, 2014

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Dermatology

Background:

  • Biofilms are microbial communities encased in extracellular polymeric substance, adhering to surfaces.
  • They are implicated in approximately 80% of human infections and increasingly in cutaneous disorders.
  • Biofilms pose clinical challenges due to persistence, difficult culturing, and antimicrobial resistance.

Purpose of the Study:

  • To highlight the significance of biofilms in human infections and skin conditions.
  • To underscore the challenges in treating biofilm-associated infections.
  • To emphasize the need for further research into biofilm molecular biology for novel therapeutic development.

Main Methods:

  • Literature review and synthesis of current research on biofilm formation, pathogenicity, and clinical implications.
  • Analysis of the challenges posed by biofilms in standard microbiological and clinical settings.
  • Discussion of the current limitations in anti-biofilm therapies.

Main Results:

  • Biofilms are a major factor in persistent and recurrent infections.
  • Conventional antimicrobial therapies are often ineffective against biofilms.
  • Evidence links biofilms to a growing number of skin disorders.

Conclusions:

  • Enhanced understanding of biofilm molecular mechanisms is crucial.
  • Novel anti-biofilm agents are needed for effective clinical treatment.
  • Targeting biofilm pathogenicity offers a promising therapeutic avenue.