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[How soon will we have artificial blood?]

¹Blodbanken i Oslo, Avdeling for immunologi og transfusjonsmedisin, Ullevål sykehus.

Nordisk Medicin

|July 4, 1998

Summary

Red cell substitutes like hemoglobin solutions and perfluorocarbons face significant challenges, limiting their widespread clinical use. Future research will focus on improving blood preservation and optimizing current blood product utilization.

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Acta anaesthesiologica Scandinavica·2006

Area of Science:

Biomedical Engineering
Hematology

Context:

Current clinical trials are evaluating artificial oxygen carriers, including stroma-free hemoglobin solutions (SFHSs) and perfluorocarbon-based substitutes.
Significant hurdles remain for the widespread clinical application of these red cell substitutes.

Purpose:

To assess the current status and future prospects of red cell substitute oxygen-carriers.
To identify the primary challenges hindering the development and implementation of artificial oxygen carriers.

Summary:

Stroma-free hemoglobin solutions (SFHSs) face issues with hemoglobin supply, limited shelf-life, and short intravascular half-life.
Perfluorocarbon use is restricted by the necessity of positive pressure ventilation for oxygen tension maintenance.
Artificial oxygen carriers are unlikely to be available for general use in the near future.

Impact:

Transfusion research will likely prioritize enhancing blood preservation techniques.
Optimizing the utilization of existing blood products will be a key focus area for immediate research efforts.

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