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Related Experiment Videos

Olfactory reference syndrome in a patient with partial epilepsy

O Devinsky1, S Khan, K Alper

  • 1Department of Neurology, New York University School of Medicine, New York, USA.

Neuropsychiatry, Neuropsychology, and Behavioral Neurology
|July 4, 1998
PubMed
Summary

Epilepsy may lead to delusional disorders. A patient with temporal lobe epilepsy developed olfactory reference syndrome, a delusion of foul body odor, suggesting a link between right hemisphere brain lesions and delusions.

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Area of Science:

  • Neurology
  • Psychiatry
  • Neuroscience

Background:

  • Epilepsy is a neurological disorder characterized by recurrent seizures.
  • Olfactory hallucinations can precede or accompany seizures.
  • Delusional disorders are psychiatric conditions involving persistent false beliefs.

Observation:

  • A 49-year-old man with right temporal lobe epilepsy experienced olfactory hallucinations before developing a chronic delusion of emitting a foul odor (olfactory reference syndrome).
  • The patient's ictal olfactory symptoms ceased as the delusional syndrome emerged.
  • A previously reported case of olfactory reference syndrome in epilepsy involved a right frontal lesion.

Findings:

  • This case highlights a potential association between right temporal lobe epilepsy and the development of delusional disorders.

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  • The progression from olfactory hallucinations to a fixed delusion suggests a possible evolution of neurological dysfunction.
  • The findings support the hypothesis linking right hemisphere lesions to delusional syndromes.

    • Implications:

    • This case contributes to understanding the complex relationship between epilepsy, specifically right-sided temporal lobe involvement, and psychiatric comorbidities.
    • It suggests that lesions in the right hemisphere may predispose individuals to developing delusional disorders.
    • Further research is warranted to explore the neurobiological mechanisms underlying this association and its clinical implications for epilepsy management.