Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Renal tubular function in beta-thalassemia

A Sumboonnanonda1, P Malasit, V S Tanphaichitr

  • 1Department of Pediatrics, Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Pediatric Nephrology (Berlin, Germany)
|July 9, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identification of mutations in the uroporphyrinogen III synthase gene in a Thai girl patient with congenital erythropoietic porphyria.

International journal of laboratory hematology·2014
Same author

Direct detection for G6PD Bangkok and G6PD Bangkok Noi mutations in the families with chronic nonspherocytic hemolytic anemia (CNSHA).

International journal of laboratory hematology·2014
Same author

Causes of inadequate protein-energy status in thalassemic children.

Asia Pacific journal of clinical nutrition·2014
Same author

Complement alternative pathway genetic variation and Dengue infection in the Thai population.

Clinical and experimental immunology·2013
Same author

Tropical distal renal tubular acidosis: clinical and epidemiological studies in 78 patients.

QJM : monthly journal of the Association of Physicians·2012
Same author

Pediatric kidney transplantation in Thailand: experience in a developing country.

Transplantation proceedings·2008
Same journal

Impact of kidney maturation on aminoglycoside exposure in term-born pediatric patients: an in silico study.

Pediatric nephrology (Berlin, Germany)·2026
Same journal

Age at onset and cumulative initial prednisolone dose predict frequent relapses in steroid-sensitive nephrotic syndrome: an individual participant data systematic review and meta-analysis of placebo-controlled RCTs.

Pediatric nephrology (Berlin, Germany)·2026
Same journal

"Life renewed, obstacles persist": a systematic review of qualitative studies on the experiences of children and adolescents post-kidney transplantation.

Pediatric nephrology (Berlin, Germany)·2026
Same journal

Preemptive rituximab for immunosuppressant withdrawal in adolescents and young adults with childhood-onset steroid-dependent nephrotic syndrome.

Pediatric nephrology (Berlin, Germany)·2026
Same journal

Characterizing children with chronic kidney disease and severe proteinuria in the United States: a retrospective analysis using electronic health records.

Pediatric nephrology (Berlin, Germany)·2026
Same journal

New therapeutic hope for rare podocytopathies.

Pediatric nephrology (Berlin, Germany)·2026
See all related articles

Beta-thalassemia patients frequently experience kidney problems, including proteinuria and tubular dysfunction. These renal abnormalities worsen with anemia severity but improve with hypertransfusion and desferrioxamine treatment.

Area of Science:

  • Nephrology
  • Pediatrics
  • Hematology

Background:

  • Renal involvement in thalassemic syndromes is understudied.
  • Beta-thalassemia is a common inherited blood disorder with potential systemic complications.

Purpose of the Study:

  • To define renal abnormalities in beta-thalassemia patients.
  • To correlate renal findings with clinical parameters like anemia severity and treatment.

Main Methods:

  • Studied 104 children with beta-thalassemia, categorized by anemia severity and treatment.
  • Compared renal function markers (proteinuria, osmolarity, enzyme levels) with 15 healthy children.
  • Assessed lipid peroxidation using malondialdehyde (MDA).

Main Results:

Related Experiment Videos

  • All beta-thalassemia patients showed higher proteinuria and lower urine osmolarity than controls.
  • Proximal tubular dysfunction was indicated by aminoaciduria and elevated N-acetyl-beta-D-glucoseminidase.
  • Severe anemia correlated with increased low-molecular-weight proteinuria and MDA, suggesting greater oxidative stress.

Conclusions:

  • Beta-thalassemia frequently causes renal abnormalities, including proximal tubular dysfunction.
  • Renal damage severity is linked to anemia degree and oxidative stress.
  • Hypertransfusion and desferrioxamine therapy may mitigate these renal complications.