Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Histomorphometric changes after small bowel transplantation

R Martín-Crespo1, J Bueno, I Alvarez

  • 1Pediatric Surgery Service, Hospital Infantil Universitario Gregorio Marañón, Madrid, Spain.

Revista Espanola De Enfermedades Digestivas
|July 10, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Phenotypic differences between equol-producing and non-equol-producing intestinal microbiota.

Beneficial microbes·2025
Same author

CDK4/6 inhibitors for metastatic breast cancer in routine clinical practice in Spain: survey of patterns of use and oncologists' perceptions.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·2025
Same author

A proposed methodology for the definition of background and reference values for trace elements in fluvial sediments.

Ecotoxicology and environmental safety·2024
Same author

Pulsed Electric Fields Effects on Proteins: Extraction, Structural Modification, and Enhancing Enzymatic Activity.

Bioelectricity·2024
Same author

First report of Equine Parvovirus-Hepatitis (EqPV-H) in Argentina.

Veterinary journal (London, England : 1997)·2024
Same author

Comparison of sediment bioavailable methods to assess the potential risk of metal(loid)s for river ecosystems.

Ecotoxicology and environmental safety·2024
Same journal

Very late entecavir resistance after more than 10 years of therapy in a treatment-naïve patient with chronic hepatitis B genotype D3.

Revista espanola de enfermedades digestivas·2026
Same journal

Beyond the scalpel ‒ The critical impact of lifestyle and tumor biology in non-cirrhotic hepatocellular carcinoma.

Revista espanola de enfermedades digestivas·2026
Same journal

Automated extraction of colonoscopy quality indicators from free-text reports using a prompt-based large language model pipeline.

Revista espanola de enfermedades digestivas·2026
Same journal

Ultra-processed food intake and risk of inflammatory bowel disease in the adult population ‒ A systematic review and meta-analysis.

Revista espanola de enfermedades digestivas·2026
Same journal

Persistent geographic inequalities in oesophageal cancer mortality in Spain despite overall declines.

Revista espanola de enfermedades digestivas·2026
Same journal

Diagnostic and therapeutic considerations in m.3243A>G-associated chronic intestinal pseudo-obstruction.

Revista espanola de enfermedades digestivas·2026
See all related articles

Small bowel transplantation can cause intestinal mucosa destruction. Cyclosporine A treatment attenuated this effect, suggesting villi and crypt measurements can monitor rejection.

Area of Science:

  • Gastroenterology
  • Transplantation immunology
  • Surgical pathology

Background:

  • Intestinal mucosa destruction is a primary cause of morbidity and mortality in human allografts.
  • Understanding histomorphometric changes is crucial for improving outcomes in small bowel transplantation.

Purpose of the Study:

  • To investigate histomorphometric changes in graft and recipient intestinal mucosa after experimental orthotopic small bowel transplantation.
  • To evaluate the impact of immunosuppression with cyclosporine A on these changes.

Main Methods:

  • A pig model was used for orthotopic small bowel transplantation.
  • Three groups were studied: control (laparotomy), transplantation without immunosuppression, and transplantation with cyclosporine A.

Related Experiment Videos

Main Results:

  • A significant reduction in total mucosal thickness (villi plus crypt) was observed in both graft and recipient mucosa.
  • Cyclosporine A administration attenuated this mucosal thinning, primarily through crypt hypertrophy.

Conclusions:

  • Villi and crypt length measurements show promise as reliable indicators for monitoring rejection post-small bowel transplantation.
  • These histomorphometric parameters may aid in early detection and management of rejection.