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Morphology of delayed-type hypersensitivity reactions in man
The Journal of Investigative Dermatology
|September 1, 1976
Summary
New research reveals delayed hypersensitivity involves more than just lymphocytes and macrophages. Basophils, mast cells, microvasculature, and clotting systems play key roles in these immune responses.
Area of Science:
- Immunology
- Pathology
Background:
- Delayed hypersensitivity was traditionally viewed as a simple infiltration of lymphocytes and macrophages in the skin.
- This limited view did not account for the complex cellular and molecular interactions involved.
Purpose of the Study:
- To present new morphologic findings that challenge existing concepts of delayed hypersensitivity.
- To highlight the roles of basophils, mast cells, microvasculature, and the clotting system in these reactions.
Main Methods:
- Review of new morphologic findings.
- Analysis of the implications of these findings for understanding delayed hypersensitivity.
Main Results:
- Delayed hypersensitivity involves an integral role for basophils, mast cells, the microvasculature, and the clotting system.
- These findings substantially alter prevalent conceptions of delayed hypersensitivity.
Conclusions:
- The established understanding of delayed hypersensitivity requires significant revision.
- Further immunologic, physiologic, and biochemical research is needed to fully integrate these findings into the pathogenesis of cell-mediated reactions.