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Related Concept Videos

Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Spongy Bone01:09

Spongy Bone

All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:

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Related Experiment Video

Updated: Jul 13, 2026

Direct Mouse Trauma/Burn Model of Heterotopic Ossification
07:01

Direct Mouse Trauma/Burn Model of Heterotopic Ossification

Published on: August 6, 2015

[Disseminated pulmonary ossification. Case report]

M Corić1, N Miculinić, S Seiwerth

  • 1Zavod za patologiju Medicinskog fakulteta, Zagreb.

Lijecnicki Vjesnik
|July 11, 1998
PubMed
Summary

Metaplastic pulmonary ossification, a rare lung condition, can present in dendriform or nodular forms. This case study details a dendriform ossification discovered incidentally during an autopsy.

Area of Science:

  • Pulmonary Pathology
  • Histopathology
  • Medical Case Reports

Background:

  • Metaplastic pulmonary ossification (MPO) is a rare condition characterized by bone formation within lung tissue.
  • It is typically associated with chronic inflammatory lung diseases or prolonged pulmonary edema.
  • MPO commonly manifests in dendriform or nodular patterns.

Observation:

  • A case of dendriform pulmonary ossification was incidentally discovered at autopsy.
  • The patient was a 66-year-old male.
  • No prior history of lung disease or edema was noted in the provided abstract.

Findings:

  • The autopsy revealed the presence of dendriform pulmonary ossification.
  • This finding was unexpected given the lack of clinical information suggesting such a condition.

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  • The study discusses potential etiological theories for this rare phenomenon.
  • Implications:

    • This case contributes to the understanding of the varied presentations of metaplastic pulmonary ossification.
    • It highlights the importance of incidental findings in autopsy studies for rare diseases.
    • Further research into the pathogenesis of MPO may be warranted.