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Related Experiment Videos

EEG abnormalities in systemic lupus erythematosus

B I Glanz1, P H Schur, S Khoshbin

  • 1Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

Clinical EEG (Electroencephalography)
|July 11, 1998
PubMed
Summary

Systemic lupus erythematosus (SLE) patients with seizures often show abnormal electroencephalograms (EEGs). Findings suggest specific left temporolimbic region damage in these SLE patients.

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Area of Science:

  • Neurology
  • Rheumatology
  • Medical Diagnostics

Background:

  • Systemic lupus erythematosus (SLE) is a complex autoimmune disease.
  • Neurological manifestations are common in SLE patients.
  • Seizures represent a significant neurological complication in SLE.

Purpose of the Study:

  • To investigate the electroencephalogram (EEG) findings in patients with SLE and a history of seizures.
  • To identify patterns of EEG abnormalities and their potential localization within the brain.

Main Methods:

  • Retrospective review of medical records for 478 SLE patients.
  • Identification of patients with a history of seizures (n=95).
  • Analysis of available EEG reports (n=62) for abnormalities and their hemispheric/regional distribution.

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Main Results:

  • 87.1% of SLE patients with seizures had abnormal EEGs.
  • Left hemisphere abnormalities were most common (79.6%), frequently localized to the left temporal leads (74.4% of left-sided abnormalities).
  • Abnormalities included theta/delta slowing and sharp wave activity.

Conclusions:

  • A high prevalence of EEG abnormalities exists in SLE patients experiencing seizures.
  • Findings suggest a predilection for left temporolimbic region involvement in these patients.
  • EEG analysis may aid in understanding the neurological impact of SLE.