Related Experiment Video
Updated: Aug 6, 2026

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice
Published on: February 3, 2012
Amiodarone-induced severe hepatitis mediated by immunological mechanisms
H W Breuer1, W Bossek, C Haferland
1Department of Internal Medicine, St. Carolus Krankenhaus, Görlitz, Germany.
Abstract:
A 64-year-old man developed a fulminant hepatitis 4 days after initiation of amiodarone treatment and a total dose of 7.1 g. The direct Coombs test was positive and became negative again soon after stopping treatment. Immediately after stopping treatment the extremely increased parameters of hepatic failure returned to normal again. A rechallenge with 200 mg of amiodarone was accompanied by a positive Coombs test which again became negative after several days. We conclude that the occurrence of an acute hepatitis soon after initiation of amiodarone treatment is mediated by immunological mechanisms. There should be high vigilance with respect to this rare life-threatening adverse drug reaction.
More Related Videos
11:36Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
Published on: May 29, 2020
06:38An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
Published on: September 12, 2019
Related Concept Videos
Allergic Drug Reactions
Antiarrhythmic Drugs: Class III Agents as Potassium Channel Blockers
Myocarditis I: Introduction
Myocarditis III: Medical Management
Hepatitis
Viral Hepatitis I: Introduction