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Increased release of IAPP in response to long-term high fat intake in mice
G T Westermark1, A Leckström, Z Ma
1Division of Molecular and Immunological Pathology, Faculty of Health Sciences, Linköping University, Sweden.
Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
|July 11, 1998
Abstract:
In the present study, mice were fed high-fat diet or standard animal chow during 6 months. Animals fed high-fat diet showed a 4.5-fold increase in the fasting plasma IAPP levels compared to animals fed standard chow. No significant change in plasma insulin levels occurred between the groups. These differences in hormone response result in a change of the molar ratio between IAPP and insulin in the group fed high-fat diet. An increased IAPP to insulin molar ratio might be important in the pathogenesis of islet amyloid in man.