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Campylobacter upsaliensis: waiting in the wings
B Bourke1, V L Chan, P Sherman
1Department of Paediatrics, University College Dublin, Ireland. bbourke@crumlin.ucd.ie
Clinical Microbiology Reviews
|July 17, 1998
Summary
Campylobacter upsaliensis is an underrecognized enteropathogen causing diarrhea and severe illnesses like hemolytic-uremic syndrome. Improved diagnostic methods are crucial for understanding its role in human disease.
Area of Science:
- Microbiology
- Infectious Diseases
- Epidemiology
Background:
- Campylobacter upsaliensis is an underappreciated human enteropathogen.
- While often causing self-limiting diarrhea, it's increasingly linked to severe conditions like spontaneous abortion and hemolytic-uremic syndrome.
- Current understanding of its virulence and molecular biology is limited.
Purpose of the Study:
- To highlight the growing clinical significance of Campylobacter upsaliensis.
- To emphasize the need for further research into its pathogenesis and virulence.
- To underscore the necessity for improved diagnostic techniques for C. upsaliensis isolation.
Main Methods:
- Review of existing epidemiological and clinical studies on Campylobacter upsaliensis.
- Analysis of the organism's sensitivity to standard antibiotic selective media.
- Identification of research gaps in understanding C. upsaliensis pathogenesis.
Main Results:
- Epidemiological data suggest C. upsaliensis plays a significant role in human enteropathogenesis.
- Severe clinical outcomes, including spontaneous abortion and hemolytic-uremic syndrome, are associated with C. upsaliensis infections.
- C. upsaliensis is sensitive to antibiotics used in common selective media, hindering its detection.
Conclusions:
- Campylobacter upsaliensis is a clinically relevant pathogen requiring greater recognition.
- Further prospective studies and in-depth pathogenesis research are essential.
- Development of effective isolation techniques is critical for accurate diagnosis and understanding disease burden.