Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Aging and apoptosis control

L D Tomei¹, S R Umansky

¹LXR Biotechnology Incorporated, Richmond, California 94804, USA.

Neurologic Clinics

|July 17, 1998

Summary

Aging is a distinct biological process, not solely linked to age-related diseases. Declining apoptosis control, crucial for cell repair, is proposed as the primary aging mechanism.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Spatial resolution of images reconstructed from a bulk-detection scanning-laser microscope.

Applied optics·2010

Same author

Mycobacterium tuberculosis DNA detection in soluble fraction of urine from pulmonary tuberculosis patients.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2008

Same author

Prevention of rat neonatal cardiomyocyte apoptosis induced by simulated in vitro ischemia and reperfusion.

Cell death and differentiation·2003

Same author

Apoptosis and the heart: a brief review.

Annals of the New York Academy of Sciences·2002

Same author

Circulating nucleic acids and apoptosis.

Annals of the New York Academy of Sciences·2001

Same author

Selective 'stencil'-aided pre-PCR cleavage of wild-type sequences as a novel approach to detection of mutant K-RAS.

Nucleic acids research·2001

Area of Science:

Gerontology
Cell Biology
Molecular Biology

Background:

Aging is a complex phenomenon distinct from age-related diseases like cancer.
While in vitro replicative senescence is studied, a unifying aging hypothesis must encompass all age-dependent processes.
Apoptosis is a fundamental cellular mechanism for maintaining tissue integrity.

Purpose of the Study:

To propose a unifying hypothesis for the biological process of aging.
To identify the rate-limiting step in aging.
To elucidate the role of apoptosis in aging.

Main Methods:

Theoretical analysis integrating existing knowledge on aging, senescence, and apoptosis.
Hypothesis formulation based on the proposed role of apoptosis in phenotypic fidelity.
Identification of apoptosis control as a critical factor.

Main Results:

Aging is proposed as a distinct process from age-related disease.
Apoptosis is identified as the key protective mechanism for preserving phenotypic fidelity.
Degeneration of apoptosis control over time is identified as the rate-limiting step in aging.

Conclusions:

A unifying hypothesis for aging centers on the decline of apoptosis control.
Apoptosis is essential for detecting and replacing damaged cells, maintaining organismal integrity.
The rate of aging is determined by the time-dependent deterioration of apoptotic regulation.

Related Experiment Videos