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Bullous pemphigoid associated with acute glomerulonephritis
M A Barnadas1, C Gelpí, V Rocamora
1Department of Dermatology, Hospital de la Sta Creu i St Pau, Barcelona, Spain.
The British Journal of Dermatology
|July 17, 1998
Summary
An 82-year-old man with bullous pemphigoid developed acute glomerulonephritis. Skin infection by Staphylococcus aureus may have triggered the kidney complication.
Area of Science:
- Nephrology
- Dermatology
- Infectious Diseases
Background:
- Bullous pemphigoid is an autoimmune blistering skin disease.
- Postinfectious glomerulonephritis is a kidney disease often following infections.
- Co-occurrence of these conditions is rare.
Observation:
- An 82-year-old male patient presented with bullous pemphigoid.
- The patient subsequently developed acute glomerulonephritis.
- Skin cultures revealed Staphylococcus aureus and methicillin-resistant S. aureus.
Findings:
- The glomerulonephritis exhibited histopathological and immunofluorescence consistent with postinfectious glomerulonephritis.
- Antibodies against 230 and 180 kDa bullous pemphigoid antigens were identified in the patient's serum.
- A potential link between the cutaneous S. aureus infection and the development of glomerulonephritis was observed.
Implications:
- This case suggests a possible association between bullous pemphigoid, S. aureus skin infection, and subsequent postinfectious glomerulonephritis.
- Cutaneous infections may play a role in triggering renal complications in susceptible individuals.
- Further research is warranted to explore the mechanisms linking skin autoimmunity and infection-induced kidney disease.