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Related Experiment Videos

Coeliac disease and epilepsy

C C Cronin1, L M Jackson, C Feighery

  • 1Department of Medicine, Cork University Hospital, Ireland.

QJM : Monthly Journal of the Association of Physicians
|July 17, 1998
PubMed
Summary

Coeliac disease appears more common in epilepsy patients. Researchers found a 1 in 44 frequency in seizure clinic attendees, suggesting a link. Cerebral calcification was not observed in coeliac disease and epilepsy patients.

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Area of Science:

  • Neurology
  • Gastroenterology
  • Immunology

Background:

  • The association between coeliac disease and epilepsy remains unclear.
  • A specific syndrome involving coeliac disease, occipital lobe epilepsy, and cerebral calcification has been reported, primarily in Italy.

Purpose of the Study:

  • To determine the prevalence of coeliac disease in patients attending a seizure clinic.
  • To investigate the occurrence of cerebral calcification in patients with coeliac disease and epilepsy.

Main Methods:

  • Screening for coeliac disease using IgA endomysial antibody via indirect immunofluorescence.
  • Histological confirmation of coeliac disease in positive cases.
  • CT scanning to assess for cerebral calcification.

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Main Results:

  • Coeliac disease was identified in 4 out of 177 patients (1 in 44) at the seizure clinic.
  • The prevalence in a control group of pregnant patients was 1 in 244.
  • Sixteen patients with both coeliac disease and epilepsy were identified; none showed cerebral calcification on CT scans.

Conclusions:

  • Coeliac disease occurs more frequently in patients with epilepsy.
  • A high index of suspicion for coeliac disease is warranted in epilepsy patients.
  • Cerebral calcification does not appear to be a common feature in this patient group and may be geographically restricted.