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Effect of age and sex on histamine-induced gastric secretion in laboratory rats
Abstract:
The effect of age and sex on histamine-stimulated 24-hr gastric secretion was assessed in the rat. Secretion tests were done in rats of both sexes at 3, 6, 9, 12, 18, and 24 mo of age. The highest 24-hr volume and acid output of gastric secretion was found in both sexes in the 9-mo age group. When related to body weight the highest 24-hr gastric secretion and acid output was found in 6-mo-old males and in 9-mo-old females. This observation may have practical value when the rat is selected as an experimental tool for the study of gastric secretory function.
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