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Related Experiment Videos

Substance P-induced depolarization accompanied by a decrease in membrane input resistance in the hamster

T Soejima1, T Endoh, T Suzuki

  • 1Department of Physiology, Tokyo Dental College, Chiba, Japan.

The Bulletin of Tokyo Dental College
|July 17, 1998
PubMed
Summary
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Substance P (SP) triggers depolarization in hamster submandibular ganglion (SMG) cells. This study reveals that cation channels linked to NK-1 receptors, primarily carrying sodium ions, generate SP-induced depolarization with decreased membrane resistance.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Pharmacology

Background:

  • Submandibular ganglion (SMG) cells in hamsters exhibit varied responses to Substance P (SP).
  • Previous work identified three subtypes of SP-induced depolarization based on membrane input resistance (Rm) changes.

Purpose of the Study:

  • To investigate the generation mechanism of SP-induced depolarization accompanied by a decrease in Rm in SMG cells.
  • To elucidate the specific ion channels and receptors involved in this cellular response.

Main Methods:

  • Utilized the current-clamp technique to record electrical activity in SMG cells.
  • Applied Substance P to observe its effects on membrane potential and resistance.

Main Results:

Related Experiment Videos

  • SP-induced depolarization associated with decreased Rm involves cation channels.
  • These cation channels are coupled with neurokinin-1 (NK-1) receptors on SMG cells.
  • Sodium ions were identified as the primary charge carriers responsible for this depolarization.

    • Conclusions:

    • The findings clarify the ionic basis of a specific type of SP-mediated signaling in SMG neurons.
    • NK-1 receptor-gated cation channels, permeable to sodium, mediate SP-induced depolarization with decreased Rm.
    • This research contributes to understanding peptidergic neurotransmission in autonomic ganglia.