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Combinatorial chemistry using polymer-supported reagents
1Lilly Research Laboratories, Lilly Corporate Center, Eli Lilly and Company Indianapolis, IN 46285, USA. Kaldor@lilly.com
Current Opinion in Chemical Biology
|June 1, 1997
Summary
Combinatorial chemistry now uses hybrid methods, including polymer-supported reagents. These tools accelerate the discovery and optimization of potential new drugs.
Area of Science:
- Medicinal Chemistry
- Organic Synthesis
Background:
- Combinatorial chemistry has evolved beyond traditional solid- and solution-phase synthesis.
- Hybrid approaches are increasingly important in modern drug discovery.
Purpose of the Study:
- To highlight the utility of polymer-supported reagents in combinatorial chemistry.
- To emphasize their role in accelerating the identification and refinement of pharmaceutical leads.
Main Methods:
- Review of hybrid combinatorial chemistry techniques.
- Focus on the application of polymer-supported reagents.
Main Results:
- Polymer-supported reagents offer significant advantages in combinatorial synthesis.
- These methods streamline the process of lead compound discovery.
Conclusions:
- Polymer-supported reagents are valuable tools in modern pharmaceutical research.
- Their application enhances the efficiency of drug discovery and optimization.