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Developments in technology and applications of microsystems

M U Kopp1, H J Crabtree, A Manz

  • 1Zeneca/SmithKline Beecham Centre for Analytical Science, Department of Chemistry, Imperial College, London, SW7 2AY, UK. m.kopp@ic.ac.uk

Current Opinion in Chemical Biology
|July 17, 1998
PubMed
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Microchip technology for miniaturized total analysis systems (microTAS) has advanced rapidly. Key innovations include improved fabrication methods and applications in biological analyses like DNA separation and cell manipulation.

Area of Science:

  • Biotechnology and Analytical Chemistry
  • Microfluidics and Lab-on-a-Chip Technology

Background:

  • Microchips have seen significant technological improvements in fabrication over the past year.
  • These advancements have enabled broader applications in diverse biological analyses.

Purpose of the Study:

  • To review recent technological improvements in microchip fabrication for microTAS.
  • To highlight key bioapplications of microTAS, particularly in areas of biological separation and manipulation.

Main Methods:

  • Focus on advancements in micromachining techniques for polymers.
  • Integration of optical detection systems on microchips.
  • Application of on-chip electrophoretic separation for biological analyses.

Main Results:

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  • Fast, cost-effective, and user-friendly polymer micromachining methods have been developed.
  • Integrated optical detection systems offer enhanced analytical capabilities.
  • Significant progress has been made in DNA and protein separations, cell manipulations, immunoassays, and polymerase chain reaction (PCR) on microchips.

Conclusions:

  • MicroTAS technology is rapidly evolving due to fabrication innovations.
  • MicroTAS platforms are increasingly vital for high-throughput and sensitive biological analyses.
  • Future research will likely focus on further integration and novel bioapplication development.