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Mast cell numbers in lymphnode lesions

R Naik1, M R Pai

  • 1Kasturba Medical College, Mangalore.

Indian Journal of Pathology & Microbiology
|July 22, 1998
PubMed
Summary
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Mast cell counts in lymph nodes reveal their role in various conditions. Increased mast cells are linked to filarial lymphadenitis and reactive nodes in breast carcinoma, while tuberculosis shows the lowest counts.

Area of Science:

  • Oncology
  • Immunology
  • Pathology

Background:

  • Mast cells are immune cells involved in inflammation and tissue repair.
  • Their role in lymph node pathology, particularly in cancer, requires further elucidation.
  • Previous studies suggest mast cell involvement in various inflammatory and neoplastic conditions.

Purpose of the Study:

  • To investigate mast cell counts in lymph nodes draining breast carcinoma.
  • To compare mast cell populations in lymph nodes with different histological lesions.
  • To assess the correlation between mast cell numbers and breast cancer metastasis.

Main Methods:

  • Histological examination and mast cell counting in 50 axillary lymph nodes draining breast carcinoma.
  • Mast cell quantification in 50 lymph nodes from various sites with diverse histological lesions.

Related Experiment Videos

  • Comparative analysis of mast cell densities across different pathological conditions.

    • Main Results:

    • Lymph nodes, excluding tuberculous lymphadenitis, showed increased mast cell numbers.
    • Highest mast cell counts were observed in filarial lymphadenitis (mean 172.80/mm2).
    • Lowest mast cell counts were found in tuberculous lymphadenitis (mean 8.87/mm2).
    • Reactive lymph nodes draining breast carcinoma had higher mast cell counts compared to those with extensive metastasis.
    • Other reactive lymph nodes showed higher mast cell counts than those draining breast carcinoma.

    Conclusions:

    • Mast cell populations vary significantly in lymph nodes affected by different pathological processes.
    • Mast cell numbers decrease with the progression of breast cancer metastasis in draining lymph nodes.
    • Mast cells may play a role in the host response to breast carcinoma and other lymph node pathologies.