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Updated: Aug 17, 2026

Generation of Human Alloantigen-specific T Cells from Peripheral Blood
Published on: November 21, 2014
Quantitative aspects of T-cell recognition: from within the antigen-presenting cell to within the T cell
1INSERM Laboratoire d'Immunologie, Hôpital de Sainte-Marguerite, Marseille, France. bernardm@ciml.univ-mrs.fr
Abstract:
T lymphocytes circulate continually throughout the peripheral lymphoid organs, where they scrutinize the surface of cells to detect the presence of nonself protein fragments. During the last years, many facets of T-cell function have been unravelled. After being bound by major histocompatibility complex (MHC) molecules, peptides derived from nonself as well as from self proteins are delivered to the cell surface. A few copies of a nonself peptide "presented" at the cell surface in the context of an MHC molecule can be detected by specific T cells, and suffice to trigger T-cell activation. This paper reviews the requirements imposed on T cells to fulfill this exquisite sensitivity.
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