Genes, structures and function of T lymphocyte antigen receptors
M Kronenberg1, B Malissen2, H N Eisen3
1Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.
Immunology Today
|October 8, 2014
Summary
Recent advances have significantly expanded our understanding of T-cell receptor genes. New data integrates structural, genetic, and immunological properties of T lymphocytes.
Area of Science:
- Immunology
- Genetics
- Structural Biology
Background:
- T-cell receptors (TCRs) are crucial for adaptive immunity.
- Recent advancements have greatly increased knowledge of TCR genes.
Purpose of the Study:
- To integrate recent structural and genetic data on T-cell receptor genes.
- To correlate genetic and structural findings with T lymphocyte immunological properties.
Main Methods:
- Data presented at a recent European Molecular Biology Organization (EMBO) workshop.
- Integration of existing structural, genetic, and immunological data.
Main Results:
- Significant expansion in the knowledge of genes encoding T-cell receptors.
- Initial steps towards integrating diverse datasets concerning T-cell receptors.
Conclusions:
- The field of T-cell receptor genetics and structure is rapidly evolving.
- Further integration of structural, genetic, and functional data is essential for understanding T lymphocyte immunology.
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