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p53 and bcl-2 protein expression in rectosigmoid adenomas
G V Papatheodoridis1, N Kapranos, M Tzouvala
1Gastroenterology Department, Tzaneion General Hospital of Piraeus, Greece.
The American Journal of Gastroenterology
|July 22, 1998
Summary
p53 and bcl-2 protein expression in rectosigmoid adenomas indicate advanced histology. This finding is linked to a higher risk of synchronous advanced proximal colon neoplasm, highlighting potential diagnostic markers.
Area of Science:
- Gastroenterology
- Oncology
- Molecular Pathology
Background:
- Rectosigmoid adenomas are precursors to colorectal cancer.
- Understanding molecular markers associated with adenoma progression is crucial for risk stratification.
Purpose of the Study:
- To investigate the association between p53 and bcl-2 protein expression in rectosigmoid adenomas.
- To correlate protein expression with adenoma histology and the presence of synchronous advanced proximal neoplasms.
Main Methods:
- Immunohistochemical analysis of p53 and bcl-2 protein expression in 76 rectosigmoid adenomas from average-risk patients.
- Adenomas were classified as advanced based on villous histology, severe dysplasia, or diameter > 1 cm.
Main Results:
- p53 was detected in 43% and bcl-2 in 93% of adenomas.
- Advanced adenomas showed significantly higher p53 positivity (63.6%) and bcl-2 score of 12 (45.5%) compared to non-advanced ones.
- Patients with p53-positive and high bcl-2 score rectosigmoid adenomas had a significantly increased risk (OR: 15.6) of synchronous advanced proximal neoplasms.
Conclusions:
- p53 expression and bcl-2 overexpression in rectosigmoid adenomas are associated with advanced histology.
- These protein expressions serve as indicators for a high risk of synchronous advanced proximal colon neoplasm.