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Cardiac Stress Test Induced by Dobutamine and Monitored by Cardiac Catheterization in Mice
15:45

Cardiac Stress Test Induced by Dobutamine and Monitored by Cardiac Catheterization in Mice

Published on: February 10, 2013

Detection of coronary artery disease using dobutamine stress echocardiography in patients with an abnormal resting

T G Hennessy1, M Siobhan Hennessy, M B Codd

  • 1Cardiovascular Research Group, Mater Misericordiae Hospital, Dublin, Ireland.

International Journal of Cardiology
|July 22, 1998
PubMed

Insights

Dobutamine stress echocardiography effectively detects coronary artery disease in patients with chest pain and abnormal ECGs. However, its low negative predictive value means further testing may be needed.

Area of Science:

  • Cardiology
  • Diagnostic Imaging

Background:

  • Coronary artery disease (CAD) is a leading cause of chest pain.
  • Electrocardiogram (ECG) abnormalities can indicate underlying cardiac issues.
  • Accurate diagnostic tools are crucial for timely CAD detection.

Purpose of the Study:

  • To evaluate the effectiveness of dobutamine stress echocardiography (DSE) in diagnosing CAD.
  • To compare DSE with exercise ECG in patients presenting with chest pain and abnormal resting ECGs.

Main Methods:

  • Dobutamine stress echocardiography was performed on 218 patients.
  • Coronary angiography was used to define significant CAD (>50% stenosis).
  • A subgroup of 69 patients underwent treadmill exercise testing.

Main Results:

  • DSE demonstrated a sensitivity of 89% and specificity of 50% for CAD detection.
  • Sensitivity for multi-vessel, double-vessel, and single-vessel disease was high (97%, 82%, 81%).
  • Treadmill exercise testing showed a lower sensitivity (37%) in a subgroup.

Conclusions:

  • Dobutamine stress echocardiography is superior to exercise ECG for identifying significant CAD.
  • The negative predictive value of DSE in this patient cohort is limited, necessitating careful interpretation.
Abstract

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