Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Interactions between genetics and environment]

P Vineis1

  • 1Servizio di Epidemiologia dei Tumori, A.O. S. Giovanni Battista, Torino.

La Medicina Del Lavoro
|July 22, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Circulating plasma phospholipid fatty acids and risk of pancreatic cancer in a large European cohort.

International journal of cancer·2018
Same author

Childhood infectious diseases and risk of multiple myeloma: an analysis of the Italian multicentre case-control study.

Epidemiology and infection·2018
Same author

An epigenome-wide association study meta-analysis of educational attainment.

Molecular psychiatry·2017
Same author

Alcohol consumption and the risk of renal cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC). Wozniak MB, Brennan P, Brenner DR, Overvad K, Olsen A, Tjønneland A, Boutron-Ruault MC, Clavel-Chapelon F, Fagherazzi G, Katzke V, Kühn T, Boeing H, Bergmann MM, Steffen A, Naska A, Trichopoulou A, Trichopoulos D, Saieva C, Grioni S, Panico S, Tumino R, Vineis P, Bueno-de-Mesquita HB, Peeters PH, Hjartåker A, Weiderpass E, Arriola L, Molina-Montes E, Duell EJ, Santiuste C, Alonso de la Torre R, Barricarte Gurrea A, Stocks T, Johansson M, Ljungberg B, Wareham N, Khaw KT, Travis RC, Cross AJ, Murphy N, Riboli E, Scelo G.Int J Cancer. 2015 Oct 15;137(8):1953-66. [Epub 2015 Apr 28]. doi: 10.1002/ijc.29559.

Urologic oncology·2017
Same author

The exposome in practice: Design of the EXPOsOMICS project.

International journal of hygiene and environmental health·2016
Same author

Drinking water vulnerability to climate change and alternatives for adaptation in coastal South and South East Asia.

Climatic change·2016
Same journal

The Evolving Landscape of Contact Dermatitis Diagnosis: A Critical Appraisal of Recent Regulatory Constraints.

La Medicina del lavoro·2026
Same journal

Work Ability and Associated Factors Among Nurses in a Teaching Hospital: A Cross-Sectional Study.

La Medicina del lavoro·2026
Same journal

Effects of Breathing Exercises Applied to Intensive Care Nurses on Fatigue and Perceived Stress: A Randomized Controlled Trial.

La Medicina del lavoro·2026
Same journal

Clinical Characteristics and Interstitial Findings on High-Resolution Computed Tomography in Patients with Coal Workers' Pneumoconiosis.

La Medicina del lavoro·2026
Same journal

Multiple Fatal Accidents at Work in Italy: How They Occur and Causal Factors for Identifying Specific Prevention Measures.

La Medicina del lavoro·2026
Same journal

Validation of the Italian Version of the Perception of Aggression Scale (POAS): A Cross-Sectional Study.

La Medicina del lavoro·2026
See all related articles

Genetic screening for occupational cancer susceptibility is ethically problematic due to potential racial discrimination from uneven "metabolic polymorphism" distribution. Scientific and ethical considerations are crucial for addressing genetic susceptibility to cancer.

Area of Science:

  • Environmental Health
  • Genetics
  • Occupational Medicine

Background:

  • The role of genetics in human pathology is increasingly recognized.
  • The "genetic fallacy" may lead to overlooking environmental factors in disease.
  • Occupational cancer risk is influenced by chemical carcinogens and individual susceptibility.

Purpose of the Study:

  • To evaluate the scientific and ethical implications of genetic screening for occupational cancer.
  • To address the potential for racial discrimination in genetic susceptibility testing.
  • To highlight the need for considering social and ethical factors alongside scientific ones.

Main Methods:

  • Review of scientific literature on genetic susceptibility to carcinogens.
  • Analysis of "metabolic polymorphisms" and their racial distribution.

Related Experiment Videos

  • Ethical and social implications assessment.

    • Main Results:

    • Genetic screening based on "metabolic polymorphisms" can lead to racial discrimination.
    • Uneven distribution of genotypes (e.g., "slow" acetylator) across racial groups is documented.
    • Scientific validity of genetic susceptibility testing is intertwined with ethical concerns.

    Conclusions:

    • Genetic screening for occupational cancer susceptibility is ethically unacceptable due to potential racial bias.
    • Ethical and social implications must be considered alongside scientific aspects of genetic susceptibility.
    • Focusing solely on genetic factors may detract from necessary environmental and occupational health interventions.