[Effect of S-adenosyl-methionine (SAMe) on some endocrine parameters in normal adult subjects]

No changes in serum prolactin, TSH and LH were noted when the antidepressant s-adenosylmethionine was given i.v. to 7 normal adults of both sexes. It would thus appear that the drug's antidepressant effect is not mediated by TSH. The results obtained are not comparable with those observed by other workers in the rat.