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Updated: Jul 30, 2026
Oxygen-Induced Retinopathy Model for Ischemic Retinal Diseases in Rodents
Published on: September 16, 2020
Reversal of blood flow in experimental branch retinal vein occlusion
G A Peyman1, B Khoobehi, A Moshfeghi
1LSU Eye Center, Louisiana State University Medical Center School of Medicine 70112-2234, USA.
Background And Objective:
To demonstrate that the obstructed vascular lumen of the experimentally induced branch retinal vein occlusion (BRVO) induces retrograde blood flow, resulting in flow from the occluded vein to the feeder arterioles.
Materials And Methods:
Photocoagulation was used to create occlusion of the branch retinal vein in a monkey model (n = 2; 1 cynomolgus, 1 rhesus). Twenty-four hours following photocoagulation, the eyes were examined for evidence of vascular occlusive disease. Vascular occlusion was proven by fluorescent vesicle angiography with scanning laser ophthalmoscopy; these results were recorded to SVHS videotape. The images were then serially analyzed frame by frame to track individual microsphere movement.
Results:
The authors observed retrograde flow proximal to the point of vessel obstruction and extending backward into the arterial system.
Conclusions:
This demonstrates the existence of retrograde flow in an experimental model of BRVO and might explain vascular complications seen in this disease process.
