Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Calcific cerebral embolism in systemic calciphylaxis

G Katsamakis1, T G Lukovits, P B Gorelick

  • 1Department of Neurological Sciences, Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL 60612-3824, USA.

Neurology
|July 23, 1998
PubMed
Summary

Calciphylaxis, a rare complication of end-stage renal disease, can affect the brain. This case highlights calciphylaxis leading to mitral annular calcification and a stroke due to a calcified cerebral embolus.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Characteristics of a Diverse Cohort of Stroke Patients with SARS-CoV-2 and Outcome by Sex.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2020
Same author

Acute ischemic stroke and transient ischemic attack: A costly business and a strategy to reduce costs (the "Time-Zero" plan).

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2015
Same author

The effects of cerebral white matter changes on cardiovascular responses to cognitive and physical activity in a stroke population.

Psychophysiology·2012
Same author

Is asymptomatic hemorrhagic transformation really innocuous?

Neurology·2012
Same author

Thalamic integrity underlies executive dysfunction in traumatic brain injury.

Neurology·2010
Same author

Teaching NeuroImages: cerebral air embolism secondary to atrial-esophageal fistula.

Neurology·2009

Area of Science:

  • Nephrology
  • Cardiology
  • Neurology

Background:

  • Calciphylaxis is a rare, severe complication in patients with end-stage renal disease (ESRD) and hyperparathyroidism.
  • It involves calcification of small blood vessels, leading to tissue ischemia and necrosis.

Observation:

  • A 26-year-old woman with chronic renal failure and systemic calciphylaxis presented with new-onset neurological deficits.
  • Imaging revealed mitral annular calcification and a right middle cerebral artery (MCA) stroke.

Findings:

  • The stroke was attributed to a calcified cerebral embolus.
  • The probable source of the embolus was identified as the mitral valve, indicating a link between mitral annular calcification and cerebral events in calciphylaxis.

Implications:

Related Experiment Videos

  • This case underscores the potential for calciphylaxis to cause significant cerebrovascular complications.
  • It highlights the importance of considering cardiac valvular calcification as a source of embolic events in patients with calciphylaxis.
  • Further research may explore screening strategies for cardiac involvement in calciphylaxis patients to prevent such events.