Related Experiment Videos
Contact dermatitis due to sodium colistimethate
S Sasaki1, Y Mitsuhashi, S Kondo
1Department of Dermatology, Yamagata University School of Medicine, Japan.
The Journal of Dermatology
|July 24, 1998
Summary
Contact allergy to colistin methanesulfonate sodium (CLMS) is rare. This report details a case of contact dermatitis in a child due to CLMS ophthalmic solution, confirmed by patch testing.
Area of Science:
- Ophthalmology
- Dermatology
- Infectious Diseases
Background:
- Colistin methanesulfonate sodium (CLMS) is a polymyxin antibiotic frequently used for bacterial infections.
- Reported cases of contact allergy to CLMS are exceptionally rare, with only two previously documented instances.
- Ophthalmic formulations of antibiotics are common in treating eye infections.
Observation:
- A 4-year-old girl developed contact dermatitis after 21 days of CLMS ophthalmic solution use.
- The patient presented with symptoms indicative of an allergic reaction to the topical medication.
- The clinical presentation suggested a delayed hypersensitivity reaction.
Findings:
- Patch testing, including 'as is' and constituent tests, confirmed CLMS as the causative agent for contact dermatitis.
- The diagnostic process involved rigorous dermatological evaluation and specific allergy testing.
- Literature review identified a paucity of documented CLMS contact allergy cases.
Implications:
- This case highlights the potential for CLMS to induce contact allergy, even in pediatric patients using ophthalmic solutions.
- Healthcare providers should consider CLMS allergy in differential diagnoses for dermatitis associated with its use.
- Further investigation into the immunogenic potential of CLMS in topical applications may be warranted.