Conformational differences between Fuc(alpha 1-3) GlcNAc and its thioglycoside analogue
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Updated: Oct 29, 2026

Structural Biology and Analytical Chemistry Approaches for Characterizing C-Glycoside Metabolic Enzymes in Human Gut Microbiota
Published on: May 23, 2025
B Aguilera1, J Jiménez-Barbero, A Fernández-Mayoralas
1Departmento de Química Orgánica Biológica, Instituto de Química Orgánica, CSIC, Madrid, Spain.
Abstract:
NOE measurements and molecular mechanics calculations have been performed to study the conformational behaviour of Fuc(alpha 1-3)GlcNAc and its thioglycoside analogue in solution. Experimental data show that, in contrast with the natural O-disaccharide, which is basically monoconformational, the S-analogue shows two conformational families, namely syn and anti.
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