An improved synthetic route to the beta-hydroxyethyl esters of 5'-nucleotides

A simple method is described for the preparation of the beta-hydroxyethyl esters of nucleoside 5'-phosphates by treatment of the appropriate 2',3'-isopropylidene nucleoside with 2-chloro-2-oxo-1,3-dioxaphospholane. Unambigous structural assignments were based on 13C nmr spectroscopy. Chemical shifts and 13C-31P spin-spin coupling constants are discussed.