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Atypical neuronal inclusion bodies in meningioangiomatosis
K Mokhtari1, T Uchihara, S Clémenceau
1Laboratoire de Neuropathologie Raymond Escourolle, Université Pierre et Marie Curie, INSERM U360, Association Claude Bernard, Hôpital de La Salpêtrière, Paris, France.
Abstract:
A case of meningioangiomatosis not associated with neurofibromatosis 2 in a 24-year-old man is reported. Abundant neurofibrillary tangles and threads, shown by immunohistochemistry and ultrastructural analysis to be similar to those seen in Alzheimer's disease, were found in the residual neuropil. Another lesion consisting of argyrophilic globular inclusion bodies with radial fibrils was found at the periphery. Single and double immunostaining with a panel of antibodies showed similarities between these inclusions and Pick bodies.