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Developmental studies on glucosamine metabolism

H Okubo, K Shibata, H Ishibashi

    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
    |September 1, 1976
    PubMed
    Summary
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    Hepatic hexosamine metabolism enzymes and amino-sugar nucleotides show distinct developmental patterns in rats, correlating with serum seromucoid levels and glycoprotein synthesis during postnatal growth.

    Area of Science:

    • Biochemistry
    • Developmental Biology
    • Metabolic Regulation

    Background:

    • Hepatic hexosamine metabolism is crucial for synthesizing amino-sugar nucleotides.
    • Serum seromucoid concentrations reflect plasma glycoprotein levels.
    • Postnatal development involves significant metabolic and physiological changes in rats.

    Purpose of the Study:

    • To investigate changes in hepatic hexosamine metabolism during postnatal development.
    • To examine the relationship between enzyme activity, nucleotide levels, and serum seromucoid concentrations.
    • To understand the regulation of hepatic glycoprotein synthesis in developing rats.

    Main Methods:

    • Measurement of hepatic L-glutamine: D-fructose-6-phosphate aminotransferase (AT) and UDP-N-acetylglucosamine 2'-epimerase (EP) activity.

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  • Quantification of hepatic UDP-GlcNAc and CMP-NANA concentrations.
  • Assay of serum seromucoid concentrations in rats at various postnatal ages.

    • Main Results:

    • Hepatic AT and EP activities were low at birth, peaked at 2 weeks, and declined to adult levels by 4 weeks.
    • Serum seromucoid concentrations increased gradually, reaching adult levels around 50 days.
    • Hepatic UDP-GlcNAc and CMP-NANA were high at birth, decreasing by 50 days, with CMP-NANA increasing significantly thereafter.

    Conclusions:

    • Hepatic hexosamine metabolism enzymes and amino-sugar nucleotides exhibit dynamic developmental patterns in rats.
    • These patterns correlate inversely with serum seromucoid concentrations during early postnatal development.
    • Hepatic amino-sugar nucleotide levels likely regulate the synthesis and secretion of plasma glycoproteins.