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New derivatives of imidazole as potential anticancer agents
1Department of Pharmaceutical Chemistry and Drug Analysis, Medical University of Lódz, Poland.
Farmaco (Societa Chimica Italiana : 1989)
|July 29, 1998
Abstract:
A series of monocyclic amidinohydrazones 2a-h was prepared from the reaction of N-(4,5-dihydro-1H-imidazol-2-yl)-N-(2-hydroxy-ethyl) hydrazine hydroiodide 1 with various aromatic aldehydes. Some of them were subjected to an esterification with acetic anhydride to give 2a-d. Compounds 2a,c,d,e,f,h and 3c were tested for their anticancer and anti-HIV activity.