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Related Experiment Videos

Laboratory animal allergy

R K Bush1, R A Wood, P A Eggleston

  • 1Department of Medicine, University of Wisconsin-Madison and the William S. Middleton Memorial Veterans Hospital, 53705, USA.

The Journal of Allergy and Clinical Immunology
|July 29, 1998
PubMed
Summary
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Occupational allergies and asthma affect one-third of laboratory animal workers. Implementing protective measures and regular screenings can significantly reduce allergen exposure and health risks for these employees.

Area of Science:

  • Occupational Health
  • Allergology
  • Veterinary Medicine

Background:

  • A significant portion of laboratory animal workers develop occupational allergies to animal danders.
  • Symptomatic asthma affects a substantial number of these allergic workers.
  • Allergen sensitization typically occurs within the initial three years of employment.

Purpose of the Study:

  • To identify the prevalence of occupational allergies and asthma in laboratory animal workers.
  • To explore risk factors associated with allergen sensitization and symptomatic asthma.
  • To recommend strategies for reducing allergen exposure and improving worker health.

Main Methods:

  • Review of existing literature on occupational allergies in laboratory animal facilities.

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  • Analysis of risk factors including atopic background and job-related exposure intensity.
  • Evaluation of personal protective devices and laboratory-level controls.

    • Main Results:

    • Approximately one-third of laboratory animal workers experience occupational allergies.
    • A third of those with allergies develop symptomatic asthma.
    • Risk factors include atopy and high-intensity exposure related to job tasks.

    Conclusions:

    • Personal protective equipment and engineering controls like laminar flow caging can mitigate exposure.
    • Regular medical screening, including questionnaires and skin testing, is advisable for early detection.
    • Worker training programs are essential for reducing personal exposure to allergens.