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A unifying hypothesis for the molecular mechanism of somatic mutation and gene conversion in rearranged

R V Blanden1, E J Steele

  • 1Division of Immunology and Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra, ACT.

Immunology and Cell Biology
|July 31, 1998
PubMed

We have reviewed available data concerning the mechanism of somatic hypermutation in rearranged variable genes of Ig in B lymphocytes of mice and the gene conversion process which generates diversity in these genes in the B lymphocytes of chickens. In our view, these data are consistent with a unifying hypothesis of diversity generating mechanisms involving reverse transcription to produce cDNA from RNA transcripts followed by homologous recombination into chromosomal DNA. Thus, seemingly different processes in the mouse and chicken may have a common molecular basis.

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