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Peripheral retinal neovascularization (Eales disease) associated with the factor V Leiden mutation
A W Eller1, F A Bontempo, H Faruki
1Department of Ophthalmology, University of Pittsburgh School of Medicine, The Eye and Ear Institute, PA 15213, USA. aeller@vision.eei.upmc.edu
Purpose:
To illustrate a case of peripheral retinal neovascularization (Eales disease) in a patient who tested positive for the factor V Leiden mutation.
Methods:
A 42-year-old woman had a 1-week history of blurred vision in her right eye. Her medical history was remarkable for a cerebrovascular accident. Ophthalmoscopy of the right eye disclosed a mild vitreous hemorrhage and a ridge of retinal neovascularization in the temporal periphery. The left fundus showed evidence of temporal retinal ischemia. A laboratory evaluation for hypercoagulability was positive for factor V Leiden mutation.
Results:
Peripheral scatter laser photocoagulation was applied to the ischemic retina, and the neovascularization regressed. The patient began taking warfarin sodium to prevent further thrombotic events.
Conclusion:
A laboratory evaluation for coagulopathy, including the factor V Leiden mutation, should be added to the examination of patients with Eales disease, especially individuals with a history of a previous thrombotic event.