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What causes p53 mutations in patients with lung cancer?
1Division of Internal Medicine and Thoracic Oncology, National Cancer Center Hospital, Tokyo 104-0045, Japan.
Oncology Reports
|July 31, 1998
Abstract:
We studied the association between occurrence of p53 mutations and both smoking history and family history of cancer (FH) in 109 lung cancer patients using the logistic regression model. A dose-response relationship between smoking defined as pack-years smoked (PY) and p53 mutations was clearly demonstrated [Odds ratio (OR) for PY 30-59: 1.92 (0.55-7.94); OR for PY 60: 4.21 (1.09-19.0); trend P=0. 04], but no association between p53 mutations and FH was obtained in male patients. In females, smoking habit [OR: 3.23 (0.48-25.4)] and FH [OR: 4.17 (0.84-25.0)] might both be associated with p53 mutations.