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Related Experiment Videos

Interaction between cephaloridine and furosemide in man

R Norrby, K Stenqvist, B Elgefors

    Scandinavian Journal of Infectious Diseases
    |January 1, 1976
    PubMed
    Summary

    Moderate furosemide (80 mg daily) prolonged cephaloridine

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    Area of Science:

    • Pharmacology
    • Nephrology
    • Clinical Pharmacy

    Background:

    • Furosemide is a potent diuretic.
    • Cephaloridine is an antibiotic.
    • Drug interactions can affect patient outcomes.

    Purpose of the Study:

    • To investigate the effect of furosemide on cephaloridine's serum half-life.
    • To assess potential impacts on renal function.

    Main Methods:

    • 14 patients received 80 mg daily oral furosemide.
    • Serum half-life of cephaloridine was measured.
    • Renal function was monitored concurrently.

    Main Results:

    • Furosemide significantly prolonged cephaloridine's serum half-life.
    • Withdrawing furosemide decreased cephaloridine's half-life.
    • No adverse effects on renal function were observed.

    Conclusions:

    • Moderate furosemide doses can alter cephaloridine pharmacokinetics.
    • Potential for increased cephalosporin nephrotoxicity with concurrent diuretic use.
    • Further research into drug interactions is warranted.

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