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Intracellular structures of retinal vascular endothelium in normal and early diabetic rats
1Lions Eye Institute, The University of Western Australia, Nedlands, Australia.
Australian and New Zealand Journal of Ophthalmology
|July 31, 1998
Abstract
Purpose:
To determine whether the arrangement of microfilaments in retinal vascular endothelium is altered in early diabetes.
Methods:
F-actin and nuclei of retinal vascular endothelial cells of normal and diabetic (28 weeks postinduction) rats were examined using confocal microscopy.
Results:
An increase in the incidence of aberrant F-actin bundle arrangement in the diabetic retinal arteriole was observed, but there was no disruption of peripheral border F-actin. The diameter of superficial capillaries was increased in diabetic rats.
Conclusion:
These changes may be related to the endothelial dysfunction demonstrated in a previous pharmacological study.