Pregnancy complicated by Cushing's syndrome

Area of Science:

• Endocrinology
• Obstetrics
• Oncology

Background:

• Cushing's syndrome, characterized by excessive cortisol, poses risks during pregnancy.
• Adrenal cortical adenomas are a common cause of Cushing's syndrome.

Observation:

• A pregnant patient presented with symptoms of Cushing's syndrome in the third trimester.
• Markedly abnormal steroid values and dexamethasone suppression tests were noted.

Findings:

• Urinary steroid excretion normalized postpartum before surgical intervention.
• A large adrenal cortical adenoma was identified as the cause.

Implications:

• Early diagnosis and management are crucial for maternal and fetal well-being.
• Surgical removal of adrenal adenomas can effectively treat Cushing's syndrome in pregnancy.