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[Biological activity of subretinal fluid in selected in vitro tests]
A Bakunowicz-Lazarczyk1, T Moniuszko, A Stankiewicz
1Katedry Okulistyki AM w Białymstoku.
Purpose:
The aim of this study was to evaluate the ability of SRF to activate autologous leucocytes derived from the peripheral blood.
Material And Method:
We studied 49 patients with idiopathic retinal detachment. Leucocyte migration inhibition, proliferation of T-lymphocytes after PHA stimulation, nonspecific suppressor activity induced by Con A, T-lymphocytes IL-2 production and basophils histamine release were assessed.
Results:
Lymphocytes obtained from patients with retinal detachment lasting 3-4 weeks exhibited in vitro in the presence of SRF: increased ability to produce IL-2, increased proliferation after PHA stimulation and increased nonspecific T-suppressor activity induced by Con A. SRF enhanced also leucocyte migration inhibition and release of histamine from basophils.