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Related Experiment Videos

Design and evaluation of layered diffusional matrices for zero-order sustained-release

Y Qiu1, N Chidambaram, K Flood

  • 1Formulation Development Centre, Pharmaceutical and Analytical R and D, Abbott Laboratories, North Chicago, IL 60064, USA. Yihong.Qiu@abbott.com

Journal of Controlled Release : Official Journal of the Controlled Release Society
|August 1, 1998
PubMed
Summary

New layered matrix systems achieve zero-order sustained release by increasing surface area over time. This overcomes limitations of traditional diffusion-controlled drug delivery devices.

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Science
  • Drug Delivery Systems

Background:

  • Diffusion-controlled matrix devices often exhibit non-linear drug release kinetics.
  • Sustained release formulations are crucial for maintaining therapeutic drug concentrations and improving patient compliance.

Purpose of the Study:

  • To develop and characterize novel layered matrix systems for zero-order sustained drug release.
  • To investigate methods for overcoming the inherent non-linear release profiles of conventional matrix systems.

Main Methods:

  • Fabrication of layered matrix systems with hydrophobic middle layers and hydrophilic/hydrophobic barrier layers.
  • In vitro drug release studies using pseudoephedrine hydrochloride as a model drug.
  • In vivo evaluation of aminophylline release modulation in beagle dogs using a crossover study.

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Main Results:

  • The novel layered matrix systems demonstrated the potential for zero-order sustained release.
  • The systems effectively compensated for decreasing release rates by providing additional releasing surface over time.
  • Preliminary in vitro/in vivo correlation studies were successfully conducted.

Conclusions:

  • The developed layered matrix systems offer a promising approach for achieving predictable zero-order drug release.
  • These systems have the potential for scalable commercial production in pharmaceutical manufacturing.