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A two-phase model for controlled drug release from biphasic polymer hydrogels

E S Kikkinides1, G C Charalambopoulou, A K Stubos

  • 1Institute of Physical Chemistry, NCSR Demokritos, Paraskevi Attikis, Greece.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|August 1, 1998
PubMed
Summary

A new two-phase model describes sustained drug release from biphasic hydrogels. Adjusting polymer properties allows control over drug release rates for optimized delivery systems.

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Area of Science:

  • Materials Science
  • Chemical Engineering
  • Drug Delivery

Background:

  • Biphasic hydrogels offer potential for controlled drug release due to their unique structure.
  • Understanding solute diffusion and desorption kinetics is crucial for optimizing drug delivery systems.

Purpose of the Study:

  • To develop a comprehensive two-phase model for sustained solute/drug release from biphasic hydrogels.
  • To investigate the influence of material properties on drug release kinetics.
  • To validate the model against experimental data and previous asymptotic models.

Main Methods:

  • Development of a two-phase diffusion-desorption model.
  • Incorporation of Langmuir isotherm for microdomain surface exchange.
  • Parametric study to analyze the effect of structural properties on release flux.

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  • Simulation of experimental results using the developed model.

    • Main Results:

    • The model accurately describes sustained release from biphasic hydrogels.
    • Model predictions align with established asymptotic models under specific conditions.
    • Parametric analysis demonstrates tunability of steady-state drug flux by altering material properties.
    • Simulations confirm the model's ability to replicate experimental drug release profiles.

    Conclusions:

    • The developed two-phase model provides a robust framework for understanding drug release from biphasic hydrogels.
    • Material structural properties can be tailored during fabrication to achieve desired drug release kinetics.
    • This work facilitates the rational design of advanced hydrogel-based drug delivery systems.