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Related Experiment Videos

Formulation and characterization of new layered diffusional matrices for zero-order sustained release

N Chidambaram1, W Porter, K Flood

  • 1Formulation Development Center, Abbott Laboratories, North Chicago, IL 60064, USA.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|August 1, 1998
PubMed
Summary

Achieving zero-order drug release from sustained-release matrices requires careful control of formulation variables. Hydrophilic barrier layers generally promote linear release profiles for pseudoephedrine hydrochloride.

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Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems
  • Materials Science

Background:

  • Sustained-release drug delivery aims to maintain therapeutic drug concentrations over time.
  • Zero-order release kinetics are desirable for predictable drug delivery and improved patient compliance.
  • Layered diffusional matrices offer a platform for controlling drug release rates.

Purpose of the Study:

  • To investigate the impact of matrix formulation variables on the in vitro release of pseudoephedrine hydrochloride.
  • To identify strategies for achieving zero-order release from layered diffusional matrices.
  • To evaluate the role of hydrophilic and hydrophobic barrier layers in modulating drug release.

Main Methods:

  • Statistical design of experiments was employed to analyze formulation variables.

Related Experiment Videos

  • Layered diffusional matrices with hydrophobic drug-containing cores were fabricated.
  • Press-coating of hydrophilic and/or hydrophobic barrier layers onto the core matrices was performed.
  • In vitro drug release studies were conducted using pseudoephedrine hydrochloride as a model compound.

    • Main Results:

    • Linear release profiles were generally achieved with hydrophilic barrier layers on one or both faces of the hydrophobic matrix.
    • The combination of hydrophilic and hydrophobic barrier layers also facilitated linear release.
    • Achieving zero-order release with hydrophobic barrier layers on both faces necessitated precise control over formulation and matrix variables.

    Conclusions:

    • Hydrophilic barrier layers are effective in promoting linear drug release from hydrophobic matrices.
    • Careful optimization of formulation and matrix properties is crucial for achieving zero-order release, particularly when using hydrophobic barrier layers.
    • Layered diffusional matrix design provides a versatile approach for developing sustained-release formulations.