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[Amiodarone induced iododerma treated by cyclosporine]

C Ricci1, M Krasovec, E Frenk

  • 1Service de Dermatologie, Centre hospitalier universitaire vaudois, Lausanne Suisse.

Annales De Dermatologie Et De Venereologie
|January 1, 1997
PubMed
Summary

Amiodarone can rarely cause severe skin reactions like iododerma. Cyclosporine therapy effectively treated a patient

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Area of Science:

  • Dermatology
  • Pharmacology

Background:

  • Iodine-containing agents are widely used in medicine, including as radiologic contrast media and for treating various conditions.
  • Vegetating iododerma is a rare but serious adverse skin reaction associated with iodine exposure.

Observation:

  • A case of iododerma is presented in an 84-year-old patient 14 months after initiating amiodarone treatment.
  • Skin lesions worsened despite amiodarone cessation, indicating a complex reaction.
  • Cyclosporine therapy led to significant improvement in the patient's skin condition.

Findings:

  • Amiodarone can exceptionally induce severe iododerma, with this case occurring after 14 months of therapy.
  • Previous exposure to iodine contrast media may play a sensitizing role but is unlikely to be the direct cause of eruption.
  • Cyclosporine demonstrated efficacy in managing amiodarone-induced iododerma.

Implications:

  • This case highlights amiodarone as a potential cause of severe iododerma.
  • Cyclosporine emerges as a promising therapeutic option for managing this rare cutaneous side effect.
  • Further research into the mechanisms and management of drug-induced iododerma is warranted.

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